When you start skipping periods and begin to experience feeling irritable, you start being unable to tolerate distractions such as "Mom, where is my blue shirt or when is dinner?" This inevitable, overwhelming, moody feeling could start early 40's. There is not a specific time frame for pre-menopause, and it is much more midlife transformation than raging hormones. Obviously, this situation creates a hormonal shift that means basically our brains are changing. If a woman can